Relationship between MLSB resistance and the prevalent virulence genotypes among Bulgarian Staphylococcus aureus isolates

Abstract The aim of this study was to investigate the rate resistance macrolide-lincosamide-streptogramin B (MLSB) antibiotics, mechanisms underlying and evaluate their relationship with virulence genes profiles 435 Bulgarian clinical isolates Staphylococcus aureus . highest observed penicillin (96.09%), followed by erythromycin clindamycin (34.02 22.76%, respectively). Of tested strains S. , 96.09% contained blaZ gene associated 11.03%, mecA responsible for methicillin resistance. most prevalent were erm genotypes presence mainly ermA ermC ermB frequency rates these genes, alone or in combinations 41.89%, 27.70%, 43.99%. majority macrolide resistant exhibited cMLS phenotype, 58.78% ( P = 0.0036). following present significantly more often among studied ones: hlg; hlg,seb; hlg,seb,sec; hlg,seb,seh; hlg,sec; hlg,sec,sei; hlg,sei; hlg,sei,sej; hlg,sej This survey found correlation between a small number isolates, contrast sensitive strains, which possessed predominantly multiple genes.